Name: Nordlund-Backlin-2013
Owner: Uppsala University, Department of Medical Sciences, Molecular Medicine
Description: Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
Created: 2013-09-10 08:37:28.0
Updated: 2017-03-29 03:43:12.0
Pushed: 2013-10-16 17:19:32.0
Homepage: http://genomebiology.com/2013/14/9/r105
Size: 212
Language: R
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Nordlund J, Bäcklin C, Wahlberg P, Busche S, Berglund EC, Eloranta M-L, Flaegstad T, Forestier E, Frost B-M, Harila-Saari A, Heyman M, Jónsson OG, Larsson R, Palle J, Rönnblom L, Schmiegelow K, Sinnett D, Söderhäll S, Pastinen T, Gustafsson MG, Lönnerholm G & Syvänen AC
Original publication: Genome Biology 2013, 14:r105
This code was produced by the groups of Molecular Medicine and Cancer Pharmacology and Computational Medicine at the Department of Medical Sciences at Uppsala University.
R version 2.15.3 or later. Packages plyr and GEOquery are required, but are installed automatically.
Parallelization using the foreach and doSNOW packages is recommended, but not required.
Figures were annotated using the biomaRt and GenomeGraphs packages. However, code for producing the figures is not included.
Download all scripts in this repo to a new directory. The most convenient way to do this on a linux/unix system is to clone the whole repo. Then run the files setup.R and analyse.R.
git clone git@github.com:Molmed/Nordlund-Backlin-2013.git
cd Nordlund-Backlin-2013
R -f setup.R
R -f analyse.R
setup.R will download all data from GEO, prepare it for use in R and store it in a new subfolder called data. analyse.R will run the analyses, produce the results and save them in a new subfolder called results. Plots are not produced.